Methods & Key Findings :

Metalloproteinases (MPs), a family of zinc-dependent endopeptidases, include matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinases (ADAMs). These enzymes are tightly associated with several diseases when not regulated by their inhibitors and activators, making them attractive targets for developing novel protein-based therapeutics . In this work , we explored application of deep learning models in screening binders to MPs.