IRB Policy and Procedures
Policies and Procedures: Human Subjects in Research
The University of Illinois at Springfield Institutional Review Board (IRB) operates under policies and procedures mandated by the U.S. Department of Health and Human Services and the Office for Human Research Protections. These policies are available for review at www.hhs.gov/ohrp/. This document is meant to serve both as a policy statement for the IRB at UIS, and as a handbook for investigators involving human subjects in their research.
Questions regarding this document or submission of materials should be directed to the UIS Human Subjects Review Officer.
The IRB policy is currently available by clicking on the link below.
Conflict of Interest – Investigators
All Investigators and key research personnel must follow the U of I Conflict of Interest Policy. Key research personnel are those individuals who (a) recruit human subjects; (b) obtain consent from human subjects; (c) collect data from human subjects; or (d) evaluate the response of human subjects. Where a conflict of interest exists, with a protocol involving human subjects, the RPI must develop and submit a conflict management plan, for the IRB to consider along with the proposed protocol. The HSRO/IRB Chair (or designee) will review the conflict management plan to determine if the conflict will adversely affect the protection of human subjects and if the management plan is adequate.
A copy of the final, approved conflict management plan will be filed in the Office of the VCAA.
The IRB application asks protocol-specific questions regarding conflict of interest for the investigators and key personnel. As part of its review process, the IRB will make a determination as to whether the conflict adversely affects the protection of human subjects.
If a conflict of interest exists, final IRB approval cannot be given until an approved conflict management plan that adequately protects the human subjects in the protocol is in place. If the conflict of interest status of an investigator changes during the course of a study, the individual is required to notify the IRB Office within ten working days of the change. The IRB will review the change as a modification to the protocol.
At the time of continuing review, the investigator will be asked whether there has been any change in the conflict of interest status relating to the research. The IRB will review conflict of interest as part of its continuing review.