Mallinckrodt Pharmaceuticals Donates HPLC to UIS

Mallinckrodt donates HPLC
Dr. Layne Morsch (left), Organic Chemistry professor, and Dr. Stephen R. Johnson (right), Biochemistry professor, discuss new HPLC with Kelly Pressler, Senior Analytical Chemist at Mallinckrodt Pharmaceuticals

Mallinckrodt Pharmaceuticals donates instrument to chemistry department at UIS

Mallinckrodt Pharmaceuticals, located in Webster Groves, Missouri, has donated a High Performance Liquid Chromatograph (HPLC) to UIS.

Kelly Pressler, Senior Analytical Chemist at Mallinckrodt, organized the donation. “At Mallinckrodt, we want to help the next generation of chemists prepare for their careers,” he said.

Mallinckrodt develops new pharmaceuticals, “mostly generics,” Pressler said. It’s a time- and labor-intensive process, according to Pressler, who mentioned a recently completed project that required hundreds of people working for three to four years.

“It speeds the process to have new chemists who are already comfortable with analyses like HPLC,” he said.

An HPLC allows scientists to separate the complex mixtures of compounds to purify, identify and quantify them.

“For example, using size-exclusion chromatography, students will be able to separate proteins in a mixture,” said Dr. Stephen R. Johnson.

The proteins in a mixture, generally, are different sizes. As the mixture passes through a column, the proteins travel at different rates—bigger proteins faster, smaller ones slower. Scientists are able to collect each different kind of protein as it comes off the end of the column.

“Having an HPLC at UIS will absolutely improve students’ education in any chemistry field,” Dr. Johnson said, “especially in biochemistry and bioanalytical chemistry.”

Johnson said students in clinical laboratory science will also learn to use the instrument to help familiarize themselves with techniques they will encounter in medical laboratories.

Used, the HPLC could sell for about $20,000, according to Pressler.

Companies have many options for selling used instruments like an HPLC, and UIS is pleased to have the donation. Thank you, Kelly, and thank you as well to your colleagues at Mallinckrodt!